Incidence of bladder cancer in a cohort of workers exposed to 4-chloro-o-toluidine while synthesising chlordimeform.
نویسندگان
چکیده
Between 1982 and 1990 seven cases of bladder cancer were detected in a group of 49 workers who were synthesising chlordimeform from 4-chloro-o-toluidine. Latency periods ranged from 15 to 23 years. The incidence of bladder tumours in this group was significantly higher than that of the cancer registers of the former GDR, Saarland, and Denmark by factors of 89.7, 53.8, and 35.0 respectively. This provides further evidence that monocyclic aromatic amines such as 4-chloro-o-toluidine may be carcinogenic in humans.
منابع مشابه
p-Chloro-o-toluidine and its hydrochloride.
There is limited evidence for the carcinogenicity of p‐chloro-o-toluidine from epidemiological studies in humans. Three cohort studies found high relative risks for urinary-bladder cancer among workers exposed to p-chloro-o-toluidine; however, confounding by coexposure to other potential urinary-bladder carcinogens could not be ruled out. Documented human exposure to p‐chloro-o-toluidine has oc...
متن کاملBladder cancer incidence among workers exposed to o-toluidine, aniline and nitrobenzene at a rubber chemical manufacturing plant.
BACKGROUND An earlier investigation found increased bladder cancer incidence among workers at a rubber chemical manufacturing plant that used o-toluidine, aniline and nitrobenzene. The cohort was expanded to include additional workers (n=1875) and updated through 2007 to assess bladder cancer with improved exposure characterisation. METHODS Work histories were updated and exposure categories ...
متن کاملIncreased bladder cancer risk among workers exposed to o-toluidine and aniline: a reanalysis.
INTRODUCTION In 1991, the US National Institute for Occupational Safety and Health (NIOSH) reported an increased bladder cancer risk in a cohort of 1749 workers potentially exposed to o-toluidine and aniline at a chemical manufacturing plant. As additional information showed that workers in certain departments had been misclassified regarding o-toluidine exposure, we therefore conducted a reana...
متن کاملA further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special reference to the chemicals 2-mercaptobenzothiazole (MBT), aniline, phenyl-â-naphthylamine and o-toluidine
Objectives—To investigate mortality and cancer morbidity in workers from a factory manufacturing chemicals for the rubber industry. Methods—The mortality (1955–96) and cancer morbidity experience (1971–92) of a cohort of 2160 male production workers from a chemical factory in north Wales were investigated. All subjects had at least 6 months employment at the factory and some employment in the p...
متن کاملMonitoring of aromatic amine exposures in workers at a chemical plant with a known bladder cancer excess.
BACKGROUND In April 1991, an excess of bladder cancer cases among workers employed at a chemical manufacturing facility in Niagara Falls, NY, was reported. This excess was primarily confined to 708 workers who had ever been employed in the rubber chemicals manufacturing area of the plant, where the aromatic amines aniline and o-toluidine have historically been used. PURPOSE An environmental a...
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عنوان ژورنال:
- British journal of industrial medicine
دوره 49 8 شماره
صفحات -
تاریخ انتشار 1992